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Updated: May 10, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Effect of beta-tricalcium phosphate/poly-l-lactide composites on radial bone defects of rabbit
Zhao-Jin Zhu1, Hao Shen, Yong-Ping Wang
1Medical Board of Graduate School of Suzhou University, Suzhou 215000, Jiangsu, China.
Objective:
To explore the effect ofβ-TCP/PLLA scaffold in repairing rabbit radial bone defects.
Methods:
Thirty New Zealand rabbits were divided into β-TCP /PLLA group (group A), pure PLLA group (group B) and contrast group (group C) randomly. The rabbits were sacrificed respectively after 4, 8, 12, 24 weeks and the X-ray film was performed at the same time to evaluate the repair effect in different groups.
Results:
X-ray film showed there was uneven low density bone callus development in defect region after 4 weeks in group A. The defect region was filled with neonate osseous tissue completely during 12-24 weeks. X-ray score revealed that repair of bone defect results significantly better than group B and group C.
Conclusions:
The β-TCP /PLLA composite is capable of repairing radial bone bone defects. β-TCP/PLLA scaffold is significant because of rapid degradation ability, good histocompatibility and osteogenic action.
