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Synthetic cannabinoids and potential reproductive consequences.

Xiaofei Sun1, Sudhansu K Dey1

  • 1Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children's Research Foundation, Cincinnati, OH 45229, USA.

Life Sciences
|July 6, 2013
PubMed
Summary

Maternal use of synthetic cannabinoids, like K2 and Spice, may harm fertility and pregnancy. Research in mice suggests these drugs impact embryo development, implantation, and birth, raising concerns for human pregnancy outcomes.

Keywords:
CannabinoidsEctopic pregnancyFemale reproductionPregnancySynthetic cannabinoids

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Area of Science:

  • Reproductive Toxicology
  • Pharmacology

Background:

  • Designer drugs, known as K2 and Spice, are synthetic cannabinoid products with rising emergency room visits.
  • Adolescents (12-20 years) are primary users, experiencing adverse effects like anxiety, seizures, and hallucinations.
  • The impact of synthetic cannabinoid use during pregnancy is largely unknown due to limited human data.

Purpose of the Study:

  • To review the known and potential adverse effects of synthetic cannabinoids on human pregnancy.
  • To synthesize findings from animal studies (mice) and limited human data.

Main Methods:

  • Literature review synthesizing data from mouse models and human studies.
  • Analysis of potential impacts on various stages of pregnancy.

Main Results:

  • In mice, synthetic cannabinoids target multiple pregnancy stages: preimplantation embryo development, oviductal transport, implantation, placentation, and parturition.
  • Potential adverse effects on female fertility and pregnancy outcomes are anticipated.

Conclusions:

  • Synthetic cannabinoid use during pregnancy poses significant risks.
  • Further research is crucial to fully understand and mitigate these risks in human pregnancies.