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Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses
Published on: March 29, 2017
Autoinflammatory disorders, pain, and neural regulation of inflammation
Michael C Chen1, Matthew H Meckfessel
1Galderma Laboratories, LP, 14501 North Freeway, Fort Worth, TX 76177, USA. michael.chen@galderma.com
Abstract:
Autoinflammatory disorders are disorders of the innate immune system that are distinct from autoimmune disorders. Dysregulation of the innate immune system, specifically an increase in interleukin-1 beta (IL-1β), gives rise to a spectrum of symptoms marked by inflammation and pain. Identification of causative gene mutations led to the discovery of the inflammasome. Many autoinflammatory disorders also have a strong pain component. The contribution of IL-1β to pain and neural involvement is underappreciated. This article provides an overview of the current autoinflammatory disorders and highlights the contribution IL-1β makes to pain in these disorders.
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