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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
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Related Experiment Video

Updated: May 10, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

Autoinflammatory diseases in pediatrics.

Jonathan S Hausmann1, Fatma Dedeoglu

  • 1Program in Rheumatology, Division of Immunology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. jonathan.hausmann@childrens.harvard.edu

Dermatologic Clinics
|July 6, 2013
PubMed
Summary
This summary is machine-generated.

Autoinflammatory diseases (AIDs) present with recurrent fevers in children. This review aids physicians in diagnosing AIDs by differentiating them from other causes of unexplained fevers.

Keywords:
Autoinflammatory diseasesCAPSFamilial Mediterranean feverHIDSPFAPAPediatricsPeriodic feverTRAPS

Related Experiment Videos

Last Updated: May 10, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

Area of Science:

  • Pediatrics
  • Immunology
  • Genetics

Background:

  • Autoinflammatory diseases (AIDs) are a group of genetic disorders characterized by recurrent inflammation.
  • Fever is a common symptom in many AIDs, often mimicking infectious diseases.
  • Diagnosing AIDs in children with recurrent unexplained fevers is crucial after excluding infection and malignancy.

Purpose of the Study:

  • To provide a comprehensive overview of the differential diagnosis of recurrent fever in children.
  • To highlight the role of autoinflammatory diseases as a cause of recurrent fevers.
  • To discuss specific monogenic AIDs and related conditions presenting with recurrent fever.

Main Methods:

  • Literature review focusing on autoinflammatory diseases and recurrent fever in pediatric populations.
  • Discussion of clinical features, diagnostic criteria, and genetic basis of various AIDs.
  • Comparative analysis of AIDs with other causes of recurrent fever, including pharyngitis and cervical adenitis.

Main Results:

  • Identified numerous monogenic AIDs causing recurrent fevers, including Familial Mediterranean Fever, Hyperimmunoglobulin D Syndrome, and Cryopyrin-Associated Periodic Syndromes.
  • Detailed specific conditions such as TNF Receptor-Associated Periodic Syndrome, IL-36 Receptor Antagonist Deficiency, and Majeed Syndrome.
  • Included granulomatous disorders like Blau Syndrome and complex conditions like Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Increased Temperature Syndrome.

Conclusions:

  • Recurrent fever in children warrants consideration of AIDs, especially when common causes are ruled out.
  • Accurate diagnosis of AIDs is essential for appropriate management and to prevent long-term complications.
  • This review serves as a guide for clinicians in the differential diagnosis of pediatric recurrent fevers, emphasizing AIDs.