Related Experiment Video
Updated: May 10, 2026
Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow
Published on: March 17, 2023
A single center comparison between three different apheresis systems for autologous and allogeneic stem cell
Sabine Flommersfeld1, Tamam Bakchoul, Gregor Bein
1Center for Transfusion Medicine and Hemotherapy, University Hospital Giessen and Marburg, Marburg Campus, Baldingerstr., 35043 Marburg, Germany.
Abstract:
Three different apheresis systems were used in our center for the collection of peripheral blood progenitor cells (PBPCs): COM.TEC (Fresenius Healthcare), COBE Spectra, and Spectra Optia (both from Caridian BCT). We compared 131 autologous and 56 allogeneic apheresis procedures to elucidate feasibility and effectiveness of the different systems. Collection efficiacy varied significantly with lowest results obtained with COBE Spectra. COM.TEC and Spectra Optia produced lower WBC contamination than COBE Spectra, but at the expense of higher product volume and longer apheresis time. High collection efficacy and a low product volume may be favorable characteristics of the Spectra Optia.
