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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

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lincRNAs: genomics, evolution, and mechanisms.

Igor Ulitsky¹, David P Bartel

¹Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

|July 6, 2013

Summary

This summary is machine-generated.

Long intervening noncoding RNAs (lincRNAs) are abundant in vertebrate genomes and crucial for gene regulation. This review explores their identification, genomics, evolution, and mechanisms of action.

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Area of Science:

Genomics
Molecular Biology
Evolutionary Biology

Background:

Long intervening noncoding RNAs (lincRNAs) are a class of transcripts originating from thousands of loci within mammalian genomes.
These molecules are increasingly recognized for their potential to regulate gene expression and influence various cellular functions.

Purpose of the Study:

To review the current understanding of lincRNAs in vertebrate animals.
To highlight methods for identifying lincRNAs.
To discuss key aspects of lincRNA genomics, evolution, and mechanisms of action.

Main Methods:

Literature review of studies on lincRNAs in vertebrates.
Analysis of genomic data related to lincRNA loci.
Examination of experimental evidence for lincRNA functions.

Main Results:

lincRNAs are widespread across vertebrate genomes.
Various computational and experimental approaches are used for lincRNA identification.
Emerging data suggest diverse roles in gene regulation and cellular processes.

Conclusions:

The field of lincRNA research is rapidly advancing, revealing their significant biological roles.
Further investigation is needed to fully elucidate lincRNA genomics, evolutionary trajectories, and precise mechanisms of action.