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Related Experiment Videos

Avoiding coagulopathy in vascular surgery.

R L Tawes1, G R Sydorak, T B Duvall

  • 1Peninsula Vascular Surgery Associates, Burlingame, California 94010.

American Journal of Surgery
|August 1, 1990
PubMed
Summary

This study presents a protocol for avoiding coagulopathy in vascular surgery using perioperative plasmapheresis. Autologous platelet-rich plasma transfusion significantly reduced homologous blood product use in cardiac and aortic surgery patients.

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Area of Science:

  • Cardiovascular Surgery
  • Hematology
  • Anesthesiology

Background:

  • Coagulopathy is a significant risk in major vascular surgery.
  • Minimizing coagulopathy requires careful management of hypothermia, hypotension, and transfusion needs.
  • Existing methods may not fully address coagulopathy prevention in complex vascular procedures.

Purpose of the Study:

  • To present a protocol for avoiding coagulopathy in vascular surgery.
  • To evaluate the efficacy of perioperative plasmapheresis and autologous platelet-rich plasma transfusion.
  • To reduce homologous blood product utilization in patients undergoing cardiac or aortic peripheral vascular surgery.

Main Methods:

  • Implementation of a perioperative protocol involving plasmapheresis.

Related Experiment Videos

  • Collection and processing of autologous blood for platelet-rich plasma preparation.
  • Transfusion of autologous platelet-rich plasma post-heparin reversal at operation completion.

    • Main Results:

    • A 50% reduction in homologous blood product requirements was observed.
    • 75% of aortic surgery patients received no homologous blood products during hospitalization.
    • Cardiac surgery patients experienced approximately a 45% reduction in homologous blood product use.

    Conclusions:

    • Perioperative plasmapheresis with autologous platelet-rich plasma transfusion is effective in minimizing coagulopathy.
    • This approach significantly decreases the need for homologous blood products in vascular surgery.
    • Autologous platelet-rich plasma reduces transfusion risks and promotes hemostasis.