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Variables of patient-controlled analgesia. 3: Test of an infusion-demand system using alfentanil
H Owen1, W G Brose, J L Plummer
1Department of Anaesthesia and Intensive Care, Flinders Medical Centre, Bedford Park, Adelaide, South Australia.
Anaesthesia
|June 1, 1990
Abstract:
Patient-controlled infusion-demand analgesia was studied using alfentanil. We were unable to identify an optimal dose and administration rate; doses required range from 100 to 900 micrograms alfentanil. The mean concentration of alfentanil in blood associated with return of pain (i.e. immediately before demand) was 58 ng/ml on day 1 and 37 ng/ml on day 2. This difference was despite similar drug consumption on both days.