Fluorescent silver nanoclusters as DNA probes
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Updated: May 10, 2026

Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
Published on: March 22, 2020
Judy M Obliosca1, Cong Liu, Hsin-Chih Yeh
1Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA.
Abstract:
Fluorescent silver nanoclusters (few atoms, quantum sized) have attracted much attention as promising substitutes for conventional fluorophores. Due to their unique environmental sensitivities, new fluorescent probes have been developed based on silver nanoclusters for the sensitive and specific detection of DNA. In this review we present the recent discoveries of activatable and color-switchable properties of DNA-templated silver nanoclusters and discuss the strategies to use these new properties in DNA sensing.
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