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Published on: March 12, 2016
[Hypotensive effect of three different formulations of brimonidine tartrate in normal eyes]
Tulio Batista Abud1, Marcio Scuoteguazza Filho, Edjane Souza Santos Oliveira
1Setor de Córnea e Cirurgia Refrativa, Hospital Oftalmológico de Sorocaba/Banco de Olhos de Sorocaba, Sorocaba (SP), Brazil. tulioabud@yahoo.com
Purpose:
To compare the hypotensive effect in normal eyes of three formulations with different concentrations of brimonidine tartrate: 0.2%; 0.15% and 0.1%.
Methods:
Prospective, randomized, double-blind study included 60 volunteers, who underwent initial ophthalmologic examination and measurement of intraocular pressure (IOP). Individuals were divided into three groups: (1) brimonidine tartrate 0.15%, (2) brimonidine tartrate 0.2% and (3) brimonidine tartrate 0.1% and randomly received one drop each of drops in each eye. The IOP was measured after 30 minutes, 1 hour and 2 hours.
Results:
We found that all concentrations of brimonidine tartrate significantly reduced intraocular pressure during the study period, with p<0.05. When analyzing the percentage difference of the hypotensive effect of each group, we found no significant difference between the studied groups: (1) -13.50%, (2) -11.50%, (3) -11.90% after 30 minutes (p=0.650); (1) -24.30%, (2) -18.60%, (3) -18.30% after 1 hour (p=0.324); (1) -29.14%, (2) -21.20%, (3) -25.60% after 2 hours (p=0.068).
Conclusion:
There is no statistically significant difference in intraocular pressure reduction (peak period) between the three formulations of brimonidine.
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