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Published on: November 9, 2018
Integrating imaging findings in evaluating the post-chemotherapy brain
K L Pomykala1, M B de Ruiter, S Deprez
1Ahmanson Translational Imaging Division, Department of Molecular & Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Brain Imaging and Behavior
|July 6, 2013
Summary
Cancer therapy can cause cognitive impairment due to chemotherapy effects on the brain. Neuroimaging reveals structural and functional brain changes, aiding understanding of these common cognitive complaints.
Area of Science:
- Neuroscience
- Oncology
- Radiology
Background:
- Cognitive complaints are frequent after cancer and cancer therapy.
- Chemotherapy's impact on the brain and its mechanisms remain unclear.
- Neuroimaging is used to explore neurological bases of cognitive changes.
Purpose of the Study:
- To review neuroimaging studies on cancer and chemotherapy-related cognitive dysfunction.
- To compare findings across different imaging modalities.
- To characterize cognitive dysfunction and understand underlying mechanisms.
Main Methods:
- Review of recent neuroimaging studies.
- Focus on non-central nervous system cancers.
- Comparison of findings from various imaging techniques.
Main Results:
- Adjuvant chemotherapy for breast cancer is associated with grey matter volume reduction and decreased white matter integrity.
- Functional imaging shows both hypo- and hyperactivations in specific brain regions months to years post-therapy.
- Consistent patterns observed across different imaging modalities.
Conclusions:
- Neuroimaging provides insights into the neurological substrates of cancer-therapy related cognitive dysfunction.
- Structural and functional brain alterations are linked to cognitive complaints.
- Further research can elucidate mechanisms and inform patient care.
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