In-depth study of homogeneity in DBS using two different techniques: results from the EBF DBS-microsampling consortium
Related Experiment Video
Updated: May 10, 2026
Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)
Published on: November 27, 2019
Zoe Cobb1, Ronald de Vries, Neil Spooner
1Quotient Bio Analytical Sciences (part of the LGC group), Newmarket Road, Fordham, Cambridgeshire, CB7 5WW, UK. zoe.cobb@quotientbioresearch.com
Background:
At the start of their work, the European Bioanalysis Forum dried blood spots microsampling consortium did not form a dedicated team to investigate the spot homogeneity. However, two teams performed experiments that produced results relating to sample homogeneity.
Results:
The data, which were produced via two different approaches (a radiolabeled and a nonradiolabeled approach), are highly complementary and demonstrate clear effects on sample inhomogeneity due to the substrate type, compound and hematocrit levels.
Conclusion:
The results demonstrate that sample inhomogeneity is a significant hurdle to the use of dried blood spots for regulated bioanalysis that should be investigated further in the method establishment phase if the whole spot is not sampled.
