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Related Concept Videos

RNA Structure01:19

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

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Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen
11:32

Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen

Published on: May 24, 2017

On topological RNA interaction structures.

Jing Qin1, Christian M Reidys

  • 1Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany.

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
|July 9, 2013
PubMed
Summary
This summary is machine-generated.

This study introduces RNA γ-interaction structures, extending topological RNA folding to two backbones. The research provides theoretical foundations and combinatorial properties for these structures, enabling recursive computation and asymptotic analysis.

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Area of Science:

  • Computational Biology
  • Bioinformatics
  • RNA Structure Prediction

Background:

  • Topological RNA pseudoknot structures folding algorithms were recently developed.
  • Existing algorithms focus on single-stranded γ-structures with bounded topological genus.

Purpose of the Study:

  • To establish theoretical foundations for folding RNA γ-interaction structures, which involve two backbones.
  • To explore the combinatorial properties of these two-backbone structures for practical applications in topological RNA folding.

Main Methods:

  • Defining RNA γ-interaction structures as two-backbone structures with genus at most γ.
  • Computing the generating function for γ-interaction structures.
  • Deriving asymptotic formulas for 0- and 1-interaction structures.

Main Results:

  • The generating function for RNA γ-interaction structures is algebraic.
  • This algebraic property allows for recursive computation of interaction structure counts.
  • Simple asymptotic formulas for 0- and 1-interaction structures were derived.

Conclusions:

  • The theoretical framework for RNA γ-interaction structures is established.
  • Combinatorial properties are key for understanding topological interaction structures.
  • The findings facilitate the folding and analysis of complex, two-backbone RNA interactions.