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Updated: May 10, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Synthesis and structural characterization of a dendrimer model compound based on a cyclotriphosphazene core with
Elena Badetti1, Vega Lloveras, Klaus Wurst
1Institut de Ciència de Materials de Barcelona ICMAB-CSIC, Campus UAB, 08193 Bellaterra, Barcelona, Spain.
Abstract:
The synthesis of the 3Gc0T zero generation dendrimer with a cyclotriphosphazene core functionalized with nitroxyl radicals in its six branches has been performed. The radical units have been used as probes to determine the orientation of the six branches in solution experimentally by Electron Paramagnetic Resonance (EPR) spectroscopy compared with the structure obtained in the solid state by X-ray diffraction. The orientation of the dendrimer branches is the same in solution as in the solid state.
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