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Surface self-diffusion of organic glasses.

Caleb W Brian1, Lian Yu

  • 1School of Pharmacy and Department of Chemistry, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.

The Journal of Physical Chemistry. A
|July 9, 2013
PubMed
Summary
This summary is machine-generated.

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Organic glass Nifedipine exhibits highly mobile surfaces, with surface diffusion being millions of times faster than bulk diffusion. This fast surface mobility impacts crystal growth and glass preparation, challenging theoretical predictions.

Area of Science:

  • Materials Science
  • Physical Chemistry
  • Amorphous Solids

Background:

  • Understanding surface dynamics in organic glasses is crucial for their application and preparation.
  • Previous studies on Indomethacin glasses highlighted significant surface mobility.
  • The role of surface diffusion in the behavior of organic glasses like Nifedipine remains an active research area.

Purpose of the Study:

  • To quantify surface self-diffusion coefficients for Nifedipine organic glass.
  • To compare the surface diffusion behavior of Nifedipine with other organic glasses like Indomethacin.
  • To investigate the relationship between surface diffusion, crystal growth, and theoretical models.

Main Methods:

  • Utilized the surface grating decay method to measure surface self-diffusion.

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  • Prepared Nifedipine glasses using vapor deposition.
  • Analyzed grating flattening kinetics at various temperatures relative to the glass transition temperature.

    • Main Results:

    • Surface self-diffusion in Nifedipine is at least 10^7 times faster than bulk diffusion, indicating a highly mobile surface.
    • Nifedipine glasses exhibit faster surface diffusion compared to Indomethacin glasses, even with similar bulk relaxation times.
    • Surface crystal growth rates in both Nifedipine and Indomethacin glasses correlate with their surface diffusivity.

    Conclusions:

    • The high surface mobility of Nifedipine suggests significant surface rearrangement during low-energy glass preparation.
    • Theoretical models (RFOT and Coupling Model) partially explain the enhanced surface mobility but disagree with Nifedipine's specific diffusion rates.
    • Experimental findings challenge existing theories, necessitating refinement in understanding surface dynamics in organic glasses.