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Effect of single dose ionizing radiation on the cellular proliferation and apparent radiosensitivity of melanoma
K H Yohem1, M D Bregman, F L Meyskens
1Department of Internal Medicine, College of Medicine, University of Arizona, Tucson 85724.
Anticancer Research
|July 1, 1990
Abstract:
An important variable in determining in vitro cell survival is the time interval between treatment and assay. One manifestation of radiation damage is the introduction of a division delay in which the post-radiation division rate is less than the pre-radiation division rate. We have examined the influence of length of incubation on radiosensitivity of murine and human melanoma cells in a soft-agar assay. In general, the longer the incubation period the larger was the median colony diameter within control or experimental groups. Hence apparent radiosensitivity decreased with increased length of incubation.