Related Experiment Video
Updated: Aug 24, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
Selective over-expression of mRNA coding for 90 KDa stress-protein in human ovarian cancer
A M Mileo1, M Fanuele, F Battaglia
1Biophysics Laboratory, Regina Elena Institute for Cancer Research, Rome, Italy.
Abstract:
The mRNA expression of the KDa stress-protein (SP) was assayed in normal and neoplastic human ovary. It was found that the expression level is low in normal ovary and in benign tumors and increases in the more advanced stages of ovarian cancer. A low level of mRNA coding for the 70 KDa SP--the most prominent among the inducible SPs-was constantly found in all specimens. No relationship was observed between SP 90 mRNA abundance and the receptor status of epidermal growth factor, estrogen and progesterone.
Related Concept Videos
RNA Splicing
Nuclear Export of mRNA

