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Related Experiment Video

Updated: May 10, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

Published on: June 8, 2017

Cerebral malaria.

Douglas G Postels¹, Gretchen L Birbeck

¹Department of Neurology and Ophthalmology, International Neurologic and Psychiatric Epidemiology Program (INPEP), Michigan State University, East Lansing, MI, USA.

Handbook of Clinical Neurology

|July 9, 2013

Summary

This summary is machine-generated.

Cerebral malaria (CM) is a severe complication of malaria, causing significant mortality and long-term neurological issues, especially in young African children. Current treatments lack effective adjuvant therapies, highlighting the urgent need for improved prevention and management strategies.

Keywords:

Pathophysiology coma intracranial pressure retinopathy sequelae

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Area of Science:

Infectious Diseases
Neurology
Parasitology

Background:

Malaria is a major global parasitic disease, causing approximately one million deaths annually.
Cerebral malaria (CM), a severe form, accounts for half of malaria-related deaths, predominantly affecting young children in sub-Saharan Africa.
The pathophysiology of CM involves complex interactions including infected erythrocyte sequestration and blood-brain barrier disruption.

Purpose of the Study:

To summarize the current understanding of cerebral malaria (CM).
To highlight the significant mortality and neurological sequelae associated with CM.
To underscore the need for improved prevention and treatment strategies.

Main Methods:

Review of existing literature on malaria and cerebral malaria.
Analysis of epidemiological data on CM prevalence and mortality.
Examination of pathophysiological mechanisms and treatment outcomes.

Main Results:

Cerebral malaria (CM) is a leading cause of death and disability, particularly in children under five in sub-Saharan Africa.
Malarial retinopathy serves as a clinical indicator of Plasmodium falciparum's pathological processes.
Adjuvant therapies have not demonstrated improved outcomes for CM patients; survivors frequently experience neurological deficits.

Conclusions:

Effective primary prevention strategies for malaria and CM are crucial.
Further research is needed to develop interventions that reduce mortality and prevent neurological sequelae in cerebral malaria.
Addressing the complex pathophysiology and sequelae of CM remains a critical global health challenge.