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Clinical pregnancy after uterus transplantation
Munire Erman Akar1, Omer Ozkan, Batu Aydinuraz
1Department of Obstetrics and Gynecology, Akdeniz University, Antalya, Turkey.
Objective:
To present the first clinical pregnancy after uterus transplantation.
Design:
Case study.
Setting:
Tertiary center.
Patient(S):
A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation.
Intervention(S):
Eighteen months after the transplant, the endometrium was prepared for transfer of the thawed embryos.
Main Outcome Measure(S):
Implantation of embryo in an allografted human uterus.
Result(S):
The first ET cycle with one day 3 thawed embryo resulted in a biochemical pregnancy. The second ET cycle resulted in a clinical pregnancy confirmed with transvaginal ultrasound visualization of an intrauterine gestational sac with decidualization.
Conclusion(S):
We have presented the first clinical pregnancy in a patient with absolute uterine infertility after uterus allotransplantation. Although the real success is the delivery of a healthy near-term baby, this clinical pregnancy is a great step forward and a proof of concept that the implantation phase works.
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