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Updated: May 10, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

[Transsexualism].

N Morel Journel¹, J-E Terrier, F Courtois

¹Centre hospitalier Lyon-Sud, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France.

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie

|July 9, 2013

Summary

This summary is machine-generated.

Gender-affirming treatments require psychological, hormonal, and surgical evaluations. While complications exist, patient well-being and satisfaction are high, justifying these interventions.

Keywords:

Metaidioplasty Méta-idioplastie Phalloplastie Phalloplasty Réassignation hormono-chirurgicale Surgical and hormonal reassignment Transsexualism Transsexualisme Vaginoplastie Vaginoplasty

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Area of Science:

Endocrinology
Surgical Procedures
Psychiatry

Context:

Transsexual conditions necessitate comprehensive evaluations.
Multidisciplinary consent is crucial for hormonal and surgical interventions.

Purpose:

To provide a critical overview of current guidelines for gender-affirming care.
To summarize key hormonal and surgical treatment modalities and their outcomes.

Summary:

Hormonal therapy involves hormone suppression and administration of desired sex hormones, with thromboembolic complications as a primary concern for estrogen therapy.
Surgical options for female-to-male (FtM) include mastectomy, hysterectomy, ovariectomy, vaginectomy, and phallic reconstruction.
Surgical options for male-to-female (MtF) include mammoplasty, vaginoplasty, and facial feminization.

Impact:

Despite a notable complication rate, patient satisfaction and psychological well-being are significantly improved, validating the therapeutic approach.
This overview highlights the importance of a multidisciplinary approach in managing complex gender-affirming care.