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Serum adipocyte fatty acid-binding protein levels are independently associated with sarcopenic obesity
Tae Nyun Kim1, Jong Chul Won, You Jeong Kim
1Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Haeundaen-gu, Busan, Republic of Korea.
Aims:
Adipocyte fatty acid-binding protein (A-FABP) plays a key role in obesity-related insulin resistance and inflammation which may be involved in the pathogenesis of sarcopenic obesity (SO). This study examined the association of SO with serum A-FABP levels in Korean adults.
Methods:
Two hundred ninety eight adults aged 20-70 years were examined using dual X-ray absorptiometry and computed tomography and measuring serum A-FABP levels. Sarcopenia was defined as the appendicular skeletal muscle mass (ASM) divided by weight (%) of <1 SD below the mean values of young adults in both sexes. Obesity was defined as visceral fat area (VFA) ≥ 100 cm(2).
Results:
Serum A-FABP levels were higher in groups with SO compared to non-SO groups in both men and women. In the unadjusted model, serum A-FABP levels were positively associated with VFA and negatively associated with ASM/weight. Even after adjusting for possible confounding factors, ASM/weight was found to be independently and negatively associated with serum A-FABP levels. In addition, multiple logistic regression analysis showed that increased serum levels of A-FABP were independently associated with the presence of SO.
Conclusions:
The present findings indicate that serum A-FABP levels may be valuable markers of the presence of SO.
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