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[Acute myocardial infarction in Charleroi: evolution of risk factors and therapeutic practices]

P Collart1, Y Coppieters, M Dramaix

  • 1Centre de recherche épidémiologie, biostatistiques et recherche clinique, École de santé publique, université Libre de Bruxelles (ULB), route de Lennik 808, CP 596, 1070 Bruxelles, Belgique.

Annales De Cardiologie Et D'Angeiologie
|July 9, 2013
PubMed

Insights

This study tracked acute coronary syndrome (ACS) in Charleroi over 12 years, finding a significant decline in 28-day mortality. Key factors influencing survival included age, diabetes, and myocardial infarction history.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • The Charleroi register is the oldest infarction registry in Belgium's French-speaking community.
  • This study examines trends from 1998-2009 for patients aged 25-69, with some analysis extended to 74.

Purpose of the Study:

  • To analyze the 12-year evolution of acute coronary risk factors, 28-day case fatality, and therapeutic practices in Charleroi.
  • To identify factors influencing patient mortality.

Main Methods:

  • Utilized Chi(2) tests to analyze treatment and risk factor evolution over time.
  • Employed logistic regression to identify factors associated with 28-day mortality.
  • Focused on patients aged 25-69 (and extended to 74) within the Charleroi register.

Main Results:

  • Observed a significant decrease in 28-day mortality.
  • Noted increased prevalence of hypertension and hypercholesterolemia.
  • Showed increased utilization of percutaneous transluminal coronary angioplasty (PTCA).
  • ß-blocker and antiplatelet drug use remained stable (approx. 75% and 90%).
  • Factors linked to fatality included age, diabetes, myocardial infarction history, hypercholesterolemia, oral antiplatelets, ß-blockers, and PTCA.

Conclusions:

  • Percutaneous transluminal coronary angioplasty (PTCA) has become the primary reperfusion strategy for acute myocardial infarction (AMI).
  • Angiotensin-converting enzyme inhibitors demonstrated no significant impact on mortality.
Abstract

Keywords:
Acute myocardial infarctionFacteurs de risqueInfarctus du myocardeMONICARegisterRegistreRisk factorsTraitementTreatment

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