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Updated: May 10, 2026
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A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
Published on: November 12, 2020
Recurrent transient monocular blindness from stenotic central retinal artery.
Seo Young Choi1, Hye-Jin Moon, Young-Eun Huh
1Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Republic of Korea.
Summary
Transient monocular blindness (TMB) can stem from central retinal artery (CRA) stenosis. This case study suggests CRA stenosis, potentially with vasospasm, as a cause of TMB, offering new diagnostic insights.
Area of Science:
- Ophthalmology
- Neurology
- Vascular Medicine
Background:
- Transient monocular blindness (TMB) is a temporary visual impairment often attributed to carotid artery embolism.
- The precise vascular pathology underlying TMB remains unidentified in numerous cases.
- Understanding the etiology of TMB is crucial for effective diagnosis and treatment.
Observation:
- A 42-year-old male experienced recurrent episodes of transient visual loss in his left eye over two months.
- Attacks of TMB were exacerbated by head flexion.
- Fluorescence angiography showed left central retinal artery (CRA) hypoperfusion during an attack.
Findings:
- Cerebral angiography revealed focal, isolated stenosis at the origin of the left CRA.
- Medical treatment with aspirin and nimodipine significantly reduced the frequency of TMB attacks.
- Central retinal artery (CRA) stenosis is identified as a potential cause of TMB.
Implications:
- This case highlights isolated CRA stenosis as a previously underrecognized cause of TMB.
- The findings suggest that a combination of static hypoperfusion and intermittent vasospasm may precipitate TMB in patients with CRA stenosis.
- Further research into CRA stenosis and vasospasm is warranted for improved TMB management.
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