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Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
Severe community-acquired pneumonia
Wendy I Sligl1, Thomas J Marrie
1Division of Infectious Diseases and Critical Care Medicine, University of Alberta, 3C1.12 WMC 8440 112 Street, Edmonton, Alberta T6G 2B7, Canada. wsligl@ualberta.ca
Abstract:
Severe community-acquired pneumonia necessitating intensive care unit admission is associated with high morbidity, mortality, and health-care cost. This review article serves to summarize the epidemiology, diagnosis, treatment, and prognosis of this common life-threatening condition. Current practice guidelines as well as the role of several scoring systems (such as the PSI, CURB-65, and IDSA/ATS criteria) used to predict CAP severity, prognosis, and site of care are reviewed. In addition, common complications and prevention strategies are discussed.
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