Related Experiment Videos
Reversal of protamine-induced catastrophic pulmonary vasoconstriction by prostaglandin E1
G J Whitman1, D Martel, M Weiss
1Department of Surgery, University of Colorado, Denver.
The Annals of Thoracic Surgery
|August 1, 1990
Abstract:
A case of catastrophic pulmonary vasoconstriction occurring after cardiopulmonary bypass after protamine reversal of heparin treated successfully with intravenous prostaglandin E1 is reported. Systemic hypotension was counteracted by epinephrine given through the left atrium. Protamine-heparin reactions are reviewed and a pathophysiological mechanism for the beneficial effect seen with prostaglandin E1 is proposed.