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Peroxiredoxin V selectively regulates IL-6 production by modulating the Jak2-Stat5 pathway

Hoon-In Choi1, Kyoung-Jin Chung2, Hee-Young Yang1

  • 1Dental Science Research Institute and the BK21 Project, Medical Research Center for Biomineralization Disorders, School of Dentistry, Chonnam National University, Gwangju, 500-757, Republic of Korea.

Free Radical Biology & Medicine
|July 9, 2013
PubMed
Summary

Mammalian peroxiredoxin V (PrdxV) regulates immune responses by inhibiting interleukin-6 production. This protein interacts with Jak2, reducing its phosphorylation and modulating lipopolysaccharide-induced signaling pathways.

Keywords:
CD14G-CSFH(2)O(2)IFN-βIL-6Jak2Jak2/Stat5 pathwayLPSMALMAPKsMD2N-acetyl-L-cysteineNACNF-κBPeroxiredoxin VPrdxVRANTESROSSOCS1Stat5TLR4TNF-αTRAMTRIFTRIF-related adaptor moleculeToll/I-1 receptor domain-containing adaptor inducing interferon-βcluster of differentiationgranulocyte colony-stimulating factorhydrogen peroxideinterferon βinterleukin 6janus kinase 2lipopolysaccaridemitogen-activated protein kinasesmyD88-adaptor-like proteinmyeloid differentiation proteinnuclear factor kappa Bperoxiredoxin Vreactive oxygen speciesregulated on activation, normal T-cell expressed, and secretedsignal transducer and activator of transcription 5suppressor of cytokine signaling 1toll like receptor 4tumor necrosis factor α

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