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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Overview of Cell Death01:30

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...

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Related Experiment Video

Updated: May 10, 2026

LPS and ATP-induced Death of PMA-differentiated THP-1 Macrophages and its Validation
06:12

LPS and ATP-induced Death of PMA-differentiated THP-1 Macrophages and its Validation

Published on: May 3, 2024

Pyroptosis: an inflammatory cell death implicates in atherosclerosis.

Wei Chang1, Jing Lin, Jiangchuan Dong

  • 1Department of Cardiology, Institute of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

Medical Hypotheses
|July 9, 2013
PubMed
Summary

Pyroptosis, an inflammatory cell death, is proposed to play a key role in atherosclerosis progression and lesion instability. Further research into this cell death mechanism is crucial for understanding cardiovascular disease development.

More Related Videos

Examination of Pyroptosis by Flow Cytometry
05:14

Examination of Pyroptosis by Flow Cytometry

Published on: May 31, 2024

Related Experiment Videos

Last Updated: May 10, 2026

LPS and ATP-induced Death of PMA-differentiated THP-1 Macrophages and its Validation
06:12

LPS and ATP-induced Death of PMA-differentiated THP-1 Macrophages and its Validation

Published on: May 3, 2024

Examination of Pyroptosis by Flow Cytometry
05:14

Examination of Pyroptosis by Flow Cytometry

Published on: May 31, 2024

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Cellular Pathology

Background:

  • Cell death and inflammation are central to both normal physiology and disease, including atherosclerosis.
  • While apoptosis and autophagy are known to occur in atherosclerosis, the precise mechanisms of cell death involved remain largely unclear.
  • Inflammation is a critical driver of atherosclerosis initiation and progression.

Purpose of the Study:

  • To investigate the potential role of pyroptosis, a pro-inflammatory form of programmed cell death, in the pathogenesis of atherosclerosis.
  • To explore the link between pyroptosis and atherosclerotic lesion instability.

Main Methods:

  • This study hypothesizes a role for pyroptosis in atherosclerosis, necessitating further experimental validation.
  • The proposed research will involve investigating the mechanisms of cell death in atherosclerotic lesions.

Main Results:

  • The study hypothesizes that pyroptosis is implicated in atherosclerosis.
  • Pyroptosis may significantly contribute to atherosclerotic lesion instability.

Conclusions:

  • Pyroptosis is a potential key mediator in atherosclerosis.
  • Understanding pyroptosis's role is vital for addressing atherosclerotic lesion instability and cardiovascular disease.