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Multidisciplinary Approach to Obesity Management: A Case Report

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Obesity in the ageing man.

K Michalakis¹, D G Goulis, A Vazaiou

¹First Department of Internal Medicine, National and Kapodestrian University of Athens, School of Medicine, "Laiko" General Hospital, Athens, Greece.

Metabolism: Clinical and Experimental

|July 9, 2013

Summary

Aging men face obesity due to body composition changes and altered energy balance. Endocrine shifts like decreased growth hormone (GH) secretion and late-onset hypogonadism (LOH) contribute to these issues.

Keywords:

ACTH ARC BM BMI BMR BT CCK CNS CRH DHEA DHEAS DHT DM2 FFM FT FT(3)FT(4)GH GHBH GHRH GnRH HDL IGF 2 IGF1 IR LH LOH MM MS NPY PAI 1 PPT PYY RMR SHBG SM SS T T(3)T(4)TBW TNF TRH TSH TT WC WHO WHR World Health Organization adrenocorticotropic hormone ageing arcuate nucleus basal metabolic rate bioavailable testosterone body mass body mass index central nervous system cholecystokinin corticotrophin releasing hormone dehydroepiandrosterone dehydroepiandrosterone sulfate diabetes mellitus type 2 dihydrotestosterone fat free mass free testosterone free thyroxine free triiodothyronine gonadotropin releasing hormone growth hormone growth hormone binding protein growth hormone releasing hormone high density lipoprotein hormonal changes insulin like growth factor 1 insulin like growth factor 2 insulin resistance late onset hypogonadism luteinising hormone man metabolic syndrome muscle mass neuropeptide Y obesity peptide tyrosine tyrosine plasminogen activator inhibitor 1 post prandial thermogenesis rT(3)resting metabolic rate reverse triiodothyronine sex hormone binding globulin skeletal mass somatostatin testosterone thyroid stimulating hormone thyrotropine releasing hormone thyroxine total body water total testosterone triiodothyronine tumor necrosis factor waist circumference waist to hip ratio

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Area of Science:

Gerontology
Endocrinology
Obesity Research

Background:

Global population aging presents significant public health challenges, with obesity being a major concern.
Obesity in aging men is multifactorial, influenced by body weight, composition, and energy balance dynamics.

Purpose of the Study:

To review and discuss current evidence on age-related changes in body composition, energy balance, and the endocrine system in men.
To explore the relationship between endocrine alterations and obesity in the aging male population.

Main Methods:

This study is a narrative review of existing scientific literature.
It synthesizes evidence on physiological and hormonal changes associated with aging and obesity in men.

Main Results:

Obesity in aging men is linked to altered body composition, energy intake, and expenditure.
Endocrine changes, including somatopenia (decreased GH secretion), late-onset hypogonadism (LOH), altered thyroid and adrenal function, and changes in appetite peptides (leptin, ghrelin), are associated with obesity.
These endocrine shifts contribute to abnormal energy balance, adipose tissue redistribution, and sarcopenia (decreased muscle mass).

Conclusions:

Understanding the intricate interplay between aging-related endocrine changes and obesity is crucial for developing effective interventions for elderly men.
Targeting these complex relationships may improve health outcomes and quality of life for aging men.