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Updated: May 9, 2026
06:38
An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Current management strategies for hepatocellular carcinoma
1Division of Gastroenterology and Hepatology Mayo Clinic College of Medicine Rochester, MN, USA - czaja.albert@mayo.edu.
Minerva Gastroenterologica E Dietologica
|July 9, 2013
Summary
Hepatocellular carcinoma surveillance using hepatic ultrasonography aids early detection. Treatment strategies for liver cancer vary based on stage, from resection and transplantation to ablation and palliative care.
Area of Science:
- Hepatology
- Oncology
- Medical Imaging
Background:
- Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality globally, with increasing incidence.
- Early detection of HCC is crucial for curative treatment, necessitating effective surveillance strategies.
Purpose of the Study:
- To outline current diagnostic and therapeutic strategies for hepatocellular carcinoma.
- To provide evidence-based recommendations for managing HCC based on disease stage.
Main Methods:
- Surveillance via hepatic ultrasonography every 6 months for high-risk individuals.
- Diagnostic imaging including computerized tomography (CT) and magnetic resonance imaging (MRI).
- Liver tissue examination for indeterminate nodules; staging using the Barcelona Clinic Liver Cancer (BCLC) system.
Main Results:
- Diagnostic criteria for HCC include arterial phase contrast uptake and washout on CT/MRI.
- Treatment selection depends on nodule size, cirrhosis status, and disease stage (e.g., resection, transplantation, radiofrequency ablation).
- Intermediate to advanced HCC managed with transarterial chemoembolization, sorafenib, or supportive care.
Conclusions:
- Timely referral to specialized centers improves outcomes for patients with complex HCC.
- Resource-limited settings require development of essential diagnostic and therapeutic capabilities for HCC management.
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