Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cochlear threshold assessment using tone-derived action potentials.

A N Salt1, A R Vora

  • 1Department of Otolaryngology, Washington University School of Medicine, St. Louis, Mo.

Audiology : Official Organ of the International Society of Audiology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bullying and harassment.

British dental journal·2019
Same author

Cochlear compound action potentials from high-level tone bursts originate from wide cochlear regions that are offset toward the most sensitive cochlear region.

Journal of neurophysiology·2019
Same author

Direct administration of 2-Hydroxypropyl-Beta-Cyclodextrin into guinea pig cochleae: Effects on physiological and histological measurements.

PloS one·2017
Same author

Perilymph pharmacokinetics of locally-applied gentamicin in the guinea pig.

Hearing research·2016
Same author

Drug delivery into the cochlear apex: Improved control to sequentially affect finely spaced regions along the entire length of the cochlear spiral.

Journal of neuroscience methods·2016
Same author

Perilymph Kinetics of FITC-Dextran Reveals Homeostasis Dominated by the Cochlear Aqueduct and Cerebrospinal Fluid.

Journal of the Association for Research in Otolaryngology : JARO·2015
Same journal

Apoptosis in the OC-k3 immortalized cell line treated with different agents.

Audiology : official organ of the International Society of Audiology·2002
Same journal

Age-related histopathological changes of the stria vascularis: an experimental model.

Audiology : official organ of the International Society of Audiology·2002
Same journal

Anatomical, metabolic and genetic aspects of age-related hearing loss in mice.

Audiology : official organ of the International Society of Audiology·2002
Same journal

Effect of ageing on otoacoustic emissions and efferent suppression in humans.

Audiology : official organ of the International Society of Audiology·2002
Same journal

Cochlear function and speech recognition in the elderly.

Audiology : official organ of the International Society of Audiology·2002
Same journal

Determination and classification of the problems experienced by hearing-impaired elderly people.

Audiology : official organ of the International Society of Audiology·2002
See all related articles

A new evoked-potential technique uses a derived action potential (AP) to detect cochlear responses to low-level tones. This method offers a more sensitive and frequency-specific way to determine hearing thresholds.

Area of Science:

  • Auditory Neuroscience
  • Otoacoustic Emissions
  • Evoked Potentials

Background:

  • Assessing cochlear function is crucial for diagnosing hearing loss.
  • Conventional auditory evoked potential (AEP) methods can be limited in sensitivity and specificity.
  • There is a need for more precise techniques to determine auditory thresholds.

Purpose of the Study:

  • To evaluate a novel evoked-potential technique for detecting cochlear responses to continuous, low-level tones.
  • To compare the sensitivity and specificity of the derived potential method with conventional auditory action potential (AP) thresholds.
  • To establish the utility of derived AP responses for determining cochlear sensitivity.

Main Methods:

  • Recording cochlear action potential (AP) responses to a probe tone.

Related Experiment Videos

  • Applying a continuous masking tone at the same frequency.
  • Subtracting the masked AP waveform from the unmasked AP to derive a new potential.
  • Testing the technique in normally hearing guinea pigs.

    • Main Results:

    • Derived AP responses were successfully recorded with masking tones below the probe stimulus threshold.
    • The mean best derived threshold in guinea pigs was 7.1 dB SPL.
    • Conventional AP thresholds in the same animals averaged 18.9 dB SPL.
    • The derived potential method demonstrated significantly better sensitivity.

    Conclusions:

    • The tone-derived response is a more sensitive method for determining cochlear thresholds.
    • This technique offers improved frequency specificity compared to conventional AP thresholds.
    • Derived AP responses provide a valuable tool for precise audiological assessment.