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Five-day partial bypass using a membrane oxygenator without systemic heparinzation.

H K Hagler, W M Powell, J W Eberle

    Transactions - American Society for Artificial Internal Organs
    |January 1, 1975
    PubMed
    Summary
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    Heparin-bound membrane oxygenators support 5-day venovenous bypass in dogs without systemic heparinization. This approach maintains oxygen transfer efficiency and avoids membrane exchange, showing promise for extended extracorporeal circuits.

    Area of Science:

    • Cardiovascular Surgery
    • Biomedical Engineering
    • Medical Devices

    Background:

    • Venovenous bypass circuits are crucial for extracorporeal support.
    • Systemic heparinization is often required to prevent thrombosis during bypass, posing bleeding risks.
    • Current membrane oxygenators may require frequent exchange due to performance deterioration.

    Purpose of the Study:

    • To evaluate the efficacy and safety of a heparin-bound membrane oxygenator in a canine venovenous bypass model.
    • To assess the feasibility of prolonged bypass (5 days) without systemic anticoagulation.
    • To determine the impact on oxygen transfer and device performance over time.

    Main Methods:

    • A heparin-bound membrane oxygenator was integrated into a venovenous bypass circuit in dogs.

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  • Animals underwent bypass for 5 days without systemic heparinization.
  • Plasma levels of SGOT and hemoglobin, along with mean linear velocity (MLW), were monitored.
  • Oxygen transfer efficiency of the membrane oxygenator was assessed throughout the study period.

    • Main Results:

    • The heparin-bound membrane oxygenator functioned effectively for 5 days in the venovenous bypass circuit.
    • Plasma SGOT, plasma hemoglobin, and MLW showed transient increases post-bypass initiation but normalized.
    • Oxygen transfer capabilities of the membrane oxygenator remained stable, without deterioration.
    • No membrane exchange was necessary during the 5-day bypass period.

    Conclusions:

    • Heparin-bound membrane oxygenators can be safely utilized in venovenous bypass for up to 5 days without systemic heparinization.
    • This technology mitigates the risks associated with systemic anticoagulation.
    • The sustained oxygen transfer efficiency eliminates the need for intra-bypass membrane exchange, enhancing clinical applicability.