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Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Examining the association between age-related macular degeneration and motor vehicle collision involvement: a
Gerald McGwin1, Bradford Mitchell, Karen Searcey
1Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, USA.
Background:
Little is known about motor vehicle collision (MVC) risk in older drivers with age-related macular degeneration (AMD). The purpose of this study is to examine associations between MVC involvement and AMD presence and severity.
Methods:
In a retrospective cohort study pooling the samples from four previous studies, we examined associations between MVC rate and older drivers with early, intermediate or advanced AMD as compared with those in normal eye health. MVC data were based on accident reports obtained from the state agency that compiles this information.
Results:
MVC rate was highest among those in normal eye health and progressively declined among those with early and intermediate disease, and then increased for those with advanced AMD. However, only for drivers with intermediate AMD was the MVC rate significantly different (lower) as compared with those in normal eye health, regardless of whether the rate was defined in terms of person-years (RR 0.34, 95% CI 0.13 to 0.89) or person-miles (RR 0.35, 95% CI 0.13 to 0.91) of driving.
Conclusions:
These results suggest that older drivers with intermediate AMD have a reduced risk of collision involvement. Further research should investigate whether self-regulatory driving practices by these drivers (avoiding challenging driving situations) underlies this reduced risk.
Insights
Older drivers with intermediate age-related macular degeneration (AMD) show a lower risk of motor vehicle collisions (MVCs). This finding suggests a potential protective effect in drivers with this specific stage of AMD.
Area of Science:
- Ophthalmology
- Geriatric Medicine
- Traffic Safety
Background:
- Limited understanding of motor vehicle collision (MVC) risk in elderly drivers with age-related macular degeneration (AMD).
- Need to investigate the relationship between AMD and driving safety in older populations.
Purpose of the Study:
- To examine the association between the presence and severity of AMD and MVC involvement in older drivers.
- To compare MVC rates in drivers with early, intermediate, and advanced AMD versus those with normal eye health.
Main Methods:
- Retrospective cohort study utilizing pooled data from four previous studies.
- Analysis of MVC data from state accident reports for drivers with varying stages of AMD.
- Comparison of MVC rates based on person-years and person-miles driven.
Main Results:
- MVC rates were highest in drivers with normal eye health, decreasing with early and intermediate AMD, and increasing with advanced AMD.
- Drivers with intermediate AMD exhibited a significantly lower MVC rate (RR 0.34-0.35) compared to drivers with normal eye health.
- No significant differences in MVC rates were observed for drivers with early or advanced AMD compared to the control group.
Conclusions:
- Older drivers with intermediate AMD demonstrate a reduced risk of MVC involvement.
- Further research is warranted to explore potential self-regulatory driving behaviors in this group, such as avoiding challenging driving conditions.

