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Updated: May 9, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
[Cerebral small vessel disease: the pathological features of cerebral amyloid angiopathy]
Jun Ogata1, Hiromichi Yamanishi, Hatsue Ishibashi-Ueda
1Hirakata General Hospital for Developmental Disorders, Japan.
Abstract:
This review describes the principal vessel histopathology in sporadic cerebral amyloid angiopathy (CAA). In sporadic CAA, β-amyloid is deposited on the lobar intracortical and leptomeningeal vessel wall. Fibrinoid necrosis, fibrohyalinous intimal thickening, microaneurysms, luminal stenosis, and inflammatory cell infiltration of the involved vessels appear subsequent to the amyloid deposition. The histopathology of sporadic CAA is described in comparison with that of hypertensive vasculopathy, both of which are the most common forms of cerebral small vessel disease.
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