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Related Experiment Video

Updated: May 9, 2026

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

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Current management of calcific aortic stenosis.

Brian R Lindman¹, Robert O Bonow, Catherine M Otto

¹Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.

Circulation Research

|July 9, 2013

Summary

Calcific aortic stenosis requires aortic valve replacement (AVR) for severe obstruction. AVR improves survival and symptoms, especially in symptomatic patients, though outcomes depend on comorbidities and disease severity.

Keywords:

aortic valve stenosis heart failure heart valve diseases heart valve prosthesis hypertrophy, left ventricular

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Area of Science:

Cardiology
Valvular Heart Disease

Background:

Calcific aortic stenosis is a progressive condition lacking effective medical treatments.
Aortic valve replacement (AVR) is the definitive treatment for severe cases.

Purpose of the Study:

To review the diagnosis, prognosis, and management of calcific aortic stenosis.
To discuss the role of echocardiography in assessing disease severity and patient response.

Main Methods:

Echocardiography is used to evaluate valve anatomy, stenosis severity, and left ventricular function.
Disease progression markers in asymptomatic patients include calcification, hemodynamic severity, and ventricular remodeling.
Patient outcomes after AVR are influenced by factors like comorbidities and fibrosis.

Main Results:

Symptomatic severe aortic stenosis indicates a high mortality risk without AVR.
AVR improves symptoms, survival, and cardiac function in symptomatic patients.
Transcatheter AVR offers an alternative for high-risk and inoperable patients.

Conclusions:

AVR is lifesaving for most symptomatic patients with severe aortic stenosis.
Bioprosthetic valves are recommended for patients over 65.
Transcatheter AVR is a viable option for specific high-risk patient groups.