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Metronidazole induced cerebellar ataxia
Aditya Hari1, B Akshaya Srikanth, G Sriranga Lakshmi
1Department of Neurology, Gandhi Medical College & Hospital, Secunderabad, India.
Indian Journal of Pharmacology
|July 9, 2013
Summary
Prolonged metronidazole use, though rare, can cause serious neurological issues like neuropathy and seizures. Complete recovery occurred after stopping the antibiotic.
Area of Science:
- Neurology
- Pharmacology
- Infectious Diseases
Background:
- Metronidazole is a common antibiotic for short-term use.
- Prolonged prescription of metronidazole is uncommon.
Observation:
- A patient experienced peripheral neuropathy, convulsions, and cerebellar ataxia.
- These symptoms emerged after a four-month course of metronidazole therapy.
Findings:
- Neurological adverse effects were linked to extended metronidazole exposure.
- Discontinuation of metronidazole led to full patient recovery.
Implications:
- Highlights the potential neurotoxicity of prolonged metronidazole use.
- Suggests careful monitoring for neurological symptoms during extended antibiotic treatment.
- Informs clinical practice regarding judicious use of metronidazole.
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