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New quinoline derivatives: synthesis and evaluation for antiinflammatory and analgesic properties--Note I
C Pellerano1, L Savini, P Massarelli
1Dipartimento Farmaco Chimico Tecnologico dell'Università, Siena.
Abstract:
New 4-anilinoquinoline-3-carboxylic acids, N-[3-carboxyquinolyl (4)]anthranilic acids and their corresponding esters were synthetized by reacting 4-chloro-3-carbethoxyquinolines with substituted anilines and methyl anthranilate respectively. All the compounds were tested for antiinflammatory and analgesic activities. Some derivatives showed a significant antiinflammatory activity comparable to that of indomethacin.