Postoperative hypotension associated with amlodipine

Continuation ofanti-hypertensive drugs peri-operatively and their influence on intra-operative hemodynamic is a major concern among anesthesiologists. Amlodipine is often favored clinically over other calcium channel blockers for its vascular selectivity and relative lack of negative ionotropy, once daily dosing and prolonged duration of effect. A post renal transplant patient who was on amlodipine for control of blood pressure was scheduled for laparoscopic cholecystectomy under general anesthesia. He developed severe post-operative hypotension which required intensive monitoring and vasopressor support.