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[Risk factors for Barrett's oesophagus in children: a case-control study]

G Sanchís Blanco1, V Ibáñez Pradas, M Couselo Jerez

  • 1Servicio de Cirugía Pediátrica, Hospital Universitari i Politècnic La Fe, Valencia. georginasb@gmail.com

Cirugia Pediatrica : Organo Oficial De La Sociedad Espanola De Cirugia Pediatrica
|July 10, 2013
PubMed

Insights

Prolonged gastroesophageal reflux (GER) exposure, without proton-pump inhibitor (PPI) treatment, is a significant risk factor for developing Barrett's esophagus (BO) in children. This finding highlights the importance of early intervention for pediatric GER.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Pathology
  • Esophageal Diseases

Context:

  • Barrett's esophagus (BO) is a rare condition in children.
  • Identifying risk factors for pediatric BO is crucial for early diagnosis and management.
  • Previous research has not clearly defined BO development factors in pediatric populations.

Purpose:

  • This case-control study aimed to identify risk factors associated with Barrett's esophagus development in children.
  • The study investigated demographic variables, symptoms, and exposure to gastroesophageal reflux (GER).

Summary:

  • A case-control study analyzed 6 pediatric patients with BO and 21 controls.
  • No significant differences were found in sex, age, clinical presentation, hiatal hernia, or Helicobacter pylori (HP) presence.
  • Increased exposure time to GER without proton-pump inhibitor (PPI) treatment was the sole identified risk factor (OR = 1.046, p = 0.021).

Impact:

  • Findings suggest that prolonged GER exposure is linked to childhood Barrett's esophagus.
  • This research underscores the importance of managing GER in pediatric patients to potentially prevent BO.
  • Early identification and treatment of GER may mitigate the risk of developing this esophageal condition in children.
Abstract

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