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Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

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Related Experiment Video

Updated: May 9, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

[Acute pancreatitis in children].

O Gómez Beltrán1, L Roldán Molleja, J I Garrido Pérez

  • 1UGC de Cirugía Pedádtrica, Hospital Universitario Reina Sofia, Córdoba. medicinaunosc@hotmail.com

Cirugia Pediatrica : Organo Oficial De La Sociedad Espanola De Cirugia Pediatrica
|July 10, 2013
PubMed
Summary

Acute pancreatitis in children is increasing but often mild. Etiology is diverse, and while serum lipase is crucial for diagnosis, especially with normal amylase, outcomes are generally favorable with no deaths in this study.

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Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Published on: June 28, 2021

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Pancreatology

Context:

  • Childhood acute pancreatitis incidence is rising.
  • Most cases are mild and do not require surgery.
  • Multiple etiologic factors contribute to pediatric pancreatitis.

Purpose:

  • To assess the etiology, clinical features, and outcomes of acute pancreatitis in children.
  • To analyze diagnostic challenges, including normoamylasemia.
  • To evaluate treatment approaches and complications in pediatric pancreatitis.

Summary:

  • A retrospective review of 24 pediatric acute pancreatitis cases (1998-2010) identified varied causes including idiopathic, biliary disease, and trauma.
  • Clinical features included abdominal pain and vomiting; lipase was vital in normoamylasemia cases. Two severe cases involved renal failure and necrosis.
  • Six patients underwent surgery; 20.8% experienced complications like pseudocysts. Mean hospital stay was 25.65 days, with no pancreatitis-related deaths.

Impact:

  • Highlights the importance of serum lipase and clinical/radiological findings in diagnosing pediatric acute pancreatitis, especially with normal amylase levels.
  • Provides insights into the diverse etiology and clinical presentation of acute pancreatitis in children.
  • Emphasizes the generally good prognosis for childhood acute pancreatitis, informing clinical management and future research directions.