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Related Concept Videos

Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...

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Related Experiment Video

Updated: May 9, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

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Cyanotic nephropathy--a morphometric analysis.

Prajakta A Gupte1, Pradeep Vaideeswar, Bhuvaneshwari M Kandalkar

  • 1Department of Pathology (Cardiovascular & Thoracic Division), Seth GS Medical College, Mumbai, India.

Congenital Heart Disease
|July 10, 2013
PubMed
Summary
This summary is machine-generated.

Cyanotic congenital heart disease (CCHD) causes significant kidney damage, including enlarged glomeruli and fibrosis. These changes worsen with decreased pulmonary blood flow and are age-dependent, impacting renal function.

Keywords:
Cyanotic Congenital Heart DiseaseCyanotic NephropathyKidney PathologyMorphometry

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Last Updated: May 9, 2026

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Area of Science:

  • Nephrology
  • Cardiology
  • Pathology

Background:

  • Cyanotic congenital heart disease (CCHD) is linked to kidney complications.
  • Understanding the histopathological changes in the kidneys of CCHD patients is crucial.

Purpose of the Study:

  • To objectively analyze the histopathological changes of cyanotic nephropathy at autopsy.
  • To compare renal findings in CCHD patients with age-matched controls.

Main Methods:

  • Retrospective study of 50 CCHD autopsies and 25 controls.
  • Morphometric analysis of Bowman's capsule, glomerular tuft, and hilar arteriole diameters.
  • Statistical analysis using unpaired t-test (P≤0.05 significant).

Main Results:

  • CCHD kidneys showed glomerulomegaly, glomerulosclerosis, and fibrosis.
  • Morphometric parameters were significantly higher in CCHD cases versus controls.
  • Changes were more pronounced with decreased pulmonary blood flow and varied significantly by age group.

Conclusions:

  • CCHD patients exhibit significant, morphometrically assessed kidney changes.
  • These renal alterations contribute to renal dysfunction.
  • Kidney changes are influenced by patient age and pulmonary blood flow status.