Related Experiment Video

Updated: May 9, 2026

Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models
09:18

Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models

Published on: February 3, 2026

Prospects of miRNA-based therapy for pancreatic cancer

Priya Pai1, Satyanarayana Rachagani, Chandrakanth Are

  • 1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE, USA.

Current Drug Targets
|July 10, 2013
PubMed

Insights

MicroRNAs (miRNAs) are key players in pancreatic cancer (PC) development and progression. This review explores how targeting these molecules offers new therapeutic and diagnostic strategies for this deadly disease.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Pancreatic cancer (PC) has a low survival rate and is often diagnosed at advanced stages.
  • Metastasis and chemotherapy resistance complicate PC treatment.
  • The molecular basis of PC remains incompletely understood.

Purpose of the Study:

  • To review the role of microRNAs (miRNAs) in pancreatic cancer.
  • To assess the potential of miRNA profiling for diagnosis.
  • To evaluate miRNA targeting as a therapeutic strategy for PC.

Main Methods:

  • Literature review of studies on miRNAs in pancreatic cancer.
  • Analysis of miRNA dysregulation in PC pathogenesis.
  • Evaluation of current and future applications of miRNAs in PC treatment.

Main Results:

  • miRNAs are frequently dysregulated in PC and contribute to its aggressiveness.
  • Targeting miRNAs could offer significant therapeutic benefits.
  • miRNA profiling shows promise for diagnostic applications.

Conclusions:

  • miRNAs are crucial in pancreatic cancer development and progression.
  • Targeting miRNAs presents a promising avenue for novel PC therapies.
  • Further research into miRNA profiling and targeting is warranted for improved PC management.

More Related Videos

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...