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Radical Autoxidation01:20

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
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Xanthones as potential antioxidants.

S S Panda1, M Chand, R Sakhuja

  • 1Department of Chemistry, University of Delhi, Delhi 110007, India. jainsc48@hotmail.com.

Current Medicinal Chemistry
|July 10, 2013
PubMed
Summary
This summary is machine-generated.

This review summarizes natural and synthetic xanthones, compounds known for their antioxidant properties. It highlights their potential as drug candidates, particularly for neuroprotection, filling a gap in existing literature.

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Area of Science:

  • Medicinal Chemistry
  • Natural Product Chemistry
  • Pharmacology

Background:

  • Xanthones (dibenzo-γ-pyrones) are oxygenated heterocycles found in plants and microorganisms.
  • They exhibit diverse biological activities, including antioxidant, anticancer, and hepatoprotective effects.
  • Their tricyclic scaffold and substituents are crucial for biological activity.

Purpose of the Study:

  • To review natural and synthetic xanthones with antioxidant activity.
  • To address the lack of comprehensive reviews on xanthone antioxidant properties.
  • To highlight xanthones as potential therapeutic agents, especially for neuroprotection.

Main Methods:

  • Literature review of natural and synthetic xanthones.
  • Focus on studies reporting antioxidant activities.
  • Categorization based on natural sources and synthetic approaches.

Main Results:

  • Xanthones possess significant antioxidant capabilities, similar to polyphenols.
  • Both isolated natural products and synthesized analogs demonstrate these properties.
  • The review consolidates information on various xanthone derivatives and their antioxidant potential.

Conclusions:

  • Xanthones are a promising class of compounds with notable antioxidant effects.
  • Further research into xanthones could lead to novel therapeutic strategies.
  • This review serves as a foundational resource for xanthone antioxidant research.