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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Modified-Release Drug Delivery Systems: Influencing Factors01:20

Modified-Release Drug Delivery Systems: Influencing Factors

Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...

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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Emerging pressure-release materials for drug delivery.

Katsuhiko Ariga1, Kohsaku Kawakami, Jonathan P Hill

  • 1Principal Investigator, Unit Director, National Institute for Materials Science (NIMS), World Premier International (WPI) Research Center for Materials Nanoarchitectonics (MANA) , 1-1 Namiki, Tsukuba, Ibaraki 305-0044 , Japan +81 29 860 4597 ; +81 29 860 4832 ; ARIGA.Katsuhiko@nims.go.j.

Expert Opinion on Drug Delivery
|July 10, 2013
PubMed
Summary

Mechanical manipulation of host-guest interactions enables simple, hand-motion-controlled drug release. This innovation offers accessible drug delivery systems for disaster relief and developing nations, empowering patients and unskilled staff.

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Drug Delivery Systems

Background:

  • Drug delivery systems are crucial for medical aid in disaster zones and developing countries, requiring user-friendly applications.
  • Current systems often lack accessibility for non-specialists or field conditions.
  • Mechanical manipulation of host-guest interactions presents a novel approach for controlled drug release.

Discussion:

  • Research explores macroscopic mechanical motions to control molecular recognition, capture, and release.
  • Pressure-induced drug release from cyclodextrin-linked gels demonstrates a feasible mechanism.
  • This method allows drug release via simple human actions like hand motion.

Key Insights:

  • Developed drug delivery systems are controlled by easy-to-perform mechanical procedures.
  • These systems enable controlled release of entrapped drugs.
  • The technology facilitates on-demand drug administration by unskilled personnel or patients.

Outlook:

  • Easy-action-based drug delivery systems hold potential for widespread application in resource-limited settings.
  • These systems can improve medical assistance for patients in less-favorable environments globally.
  • Further development could enhance the accessibility and efficacy of field-based medical treatments.