Generalised peripheral oedema associated with amlodipine therapy in two dogs

Area of Science:

• Veterinary Pharmacology
• Canine Adverse Drug Reactions

Background:

• Amlodipine is a commonly prescribed calcium channel blocker for cardiovascular conditions in dogs.
• Adverse drug reactions (ADRs) can occur with any medication, necessitating vigilance in veterinary practice.

Observation:

• Two cases of dogs experiencing adverse events potentially linked to amlodipine therapy are presented.
• Case 1: Peripheral edema resolved after amlodipine discontinuation.
• Case 2: Diffuse peripheral edema developed rapidly, leading to euthanasia, despite amlodipine initiation for hypertension.

Findings:

• Diffuse peripheral edema is identified as a potential serious adverse drug event associated with amlodipine in dogs.
• The edema in both cases was severe and required clinical investigation to rule out other causes.
• Rapid onset of edema within 72 hours of amlodipine administration was noted in the second case.

Implications:

• Veterinarians must be aware of the potential for severe, diffuse edema as an ADR to amlodipine in dogs.
• This finding highlights the importance of thorough patient monitoring and risk-benefit assessment for commonly used veterinary drugs.
• Further research into the mechanisms and incidence of amlodipine-induced edema in canines is warranted.