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Thyroid Doppler indices in patients with sickle cell disease
Sinem Karazincir1, Ali Balci, Zafer Yonden
1Mustafa Kemal University, Faculty of Medicine, Department of Radiology.
Clinical Imaging
|July 10, 2013
Summary
Sickle cell disease (SCD) patients show altered thyroid blood flow, with higher resistance and pulsatility indices and smaller thyroid volume compared to controls. These changes suggest impaired thyroid microcirculation in SCD.
Area of Science:
- Vascular Medicine
- Endocrinology
- Hematology
Background:
- Sickle cell disease (SCD) is a genetic blood disorder affecting red blood cells.
- Thyroid function can be impacted by systemic diseases.
- Intrathyroidal hemodynamics in SCD are not well understood.
Purpose of the Study:
- To assess intrathyroidal hemodynamic changes in patients with sickle cell disease.
- To evaluate thyroidal volume in sickle cell disease patients.
- To correlate Doppler ultrasonography findings with SCD.
Main Methods:
- Color Doppler ultrasonography was used to examine 32 homozygous SCD patients and 32 controls.
- Participants were free of clinical or laboratory evidence of thyroid disease.
- Resistance index (RI) and pulsatility index (PI) were measured.
Main Results:
- SCD patients exhibited significantly higher intrathyroidal RI and PI compared to the control group.
- Thyroid volume was significantly lower in SCD patients than in controls.
- These findings indicate altered intrathyroidal hemodynamics in SCD.
Conclusions:
- Elevated intrathyroidal RI and PI, along with reduced thyroid volume, suggest impaired thyroid microcirculation in SCD.
- Further research is necessary to elucidate the relationship between Doppler parameters and thyroid function in SCD.
- These findings highlight potential vascular complications of SCD affecting the thyroid gland.
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