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Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model
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Published on: July 29, 2012

Exercise-induced decrease in myocardial high-energy phosphate metabolites in patients with Chagas heart disease.

Ana Maria Betim Paes Leme1, Vera Maria Cury Salemi, Robert G Weiss

  • 1Faculdade de Medicina, Heart Institute, Hospital das Clínicas, Universidade de São Paulo, São Paulo, Brazil.

Journal of Cardiac Failure
|July 10, 2013
PubMed
Summary

Cardiac metabolic response in Chagas disease patients was studied using (31)P magnetic resonance spectroscopy (MRS). Patients showed reduced high-energy phosphates at rest and during exercise, indicating potential myocardial ischemia and a tool for intervention research.

Keywords:
Cardiomyopathymagnetic resonance imagingmicrovascular dysfunctionpathophysiologyphosphatesspetroscopy

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Area of Science:

  • Cardiology
  • Metabolic Research
  • Medical Imaging

Background:

  • The cardiac metabolic response to exercise in Chagas disease is not fully understood.
  • Chagas disease can lead to cardiac complications, affecting myocardial energy metabolism.

Purpose of the Study:

  • To investigate cardiac energetic metabolism in Chagas disease patients during isometric handgrip exercise.
  • To compare metabolic responses between different patient groups and healthy controls.

Main Methods:

  • Utilized (31)P magnetic resonance spectroscopy (MRS) to measure myocardial phosphocreatine to [β-phosphate]adenosine triphosphate ratio (PCr/β-ATP).
  • Evaluated 28 Chagas disease patients (categorized by cardiac function and ECG) and 8 healthy controls.
  • Measured PCr/β-ATP at rest and during isometric handgrip exercise.

Main Results:

  • Chagas patients exhibited reduced resting cardiac PCr/β-ATP compared to controls, with lower levels in patients with systolic dysfunction.
  • Healthy controls showed no significant change in PCr/β-ATP during exercise.
  • Chagas patients demonstrated a significant exercise-induced decrease in PCr/β-ATP, suggesting impaired energy metabolism.

Conclusions:

  • Myocardial high-energy phosphates are diminished at rest in Chagas heart disease, particularly with left ventricular dysfunction.
  • Exercise induces a decline in cardiac high-energy phosphates in Chagas patients, resembling myocardial ischemia.
  • This metabolic approach using (31)P-MRS may serve as a tool for evaluating interventions in Chagas disease.