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Related Concept Videos

Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
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Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
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Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
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Hepatic Encephalopathy01:29

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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...

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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
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Published on: August 18, 2020

Limbic encephalitis and psychosis.

Kairav Shah1, Nkiruka Iloh, Paula Tabares

  • 1PGY-4, Department of Psychiatry, Harlem Hospital Center, New York, NY 10037.

General Hospital Psychiatry
|July 10, 2013
PubMed
Summary
This summary is machine-generated.

Limbic encephalitis (LE) can present with psychosis. Early recognition and treatment with methylprednisolone can resolve symptoms and prevent lasting behavioral deficits.

Keywords:
Limbic encephalitisPsychosisSeronegative limbic encephalitis

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Area of Science:

  • Neurology
  • Psychiatry
  • Neuroimmunology

Background:

  • Limbic encephalitis (LE) is an inflammatory condition affecting the limbic system.
  • Psychotic symptoms can be an initial presentation of LE, complicating diagnosis.

Observation:

  • A case report details a woman experiencing acute psychotic symptoms as the first sign of LE.
  • Magnetic resonance imaging (MRI) revealed hyperintensity in the bilateral temporal lobes, indicative of inflammation.

Findings:

  • Despite negative results for paraneoplastic and autoimmune antibodies, the patient's psychosis resolved.
  • Treatment with methylprednisolone led to symptom remission, suggesting an autoimmune or inflammatory basis responsive to corticosteroids.

Implications:

  • Increased awareness of LE's diverse presentations, including psychosis, is crucial for timely diagnosis across medical disciplines.
  • Prompt recognition and management of LE can prevent irreversible neurological and behavioral deficits.