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Related Concept Videos

Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
Vertebral Column: Regions and Curvature01:16

Vertebral Column: Regions and Curvature

The vertebral column or spine is a flexible column that supports the head, neck, and body and  allows for their movements. It also protects the spinal cord.
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form the...

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Related Experiment Video

Updated: May 9, 2026

Uniportal Full Endoscopic Posterolateral Transforaminal Lumbar Interbody Fusion
10:40

Uniportal Full Endoscopic Posterolateral Transforaminal Lumbar Interbody Fusion

Published on: June 6, 2025

When gout involves the spine: five patients including two inaugural cases.

Daniel Wendling1, Clément Prati, Bruno Hoen

  • 1Service de rhumatologie, CHRU de Besançon, Besançon, France.

Joint Bone Spine
|July 10, 2013
PubMed
Summary

Spinal gout is rare and challenging to diagnose, often presenting without prior gout history. Prompt treatment with colchicine or surgery leads to favorable outcomes in these challenging cases.

Keywords:
DiskitisFacet joint arthritisGoutSpine

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Area of Science:

  • Rheumatology
  • Spinal Medicine
  • Diagnostic Imaging

Background:

  • Spinal involvement in gout is infrequent and poses diagnostic difficulties.
  • Gout typically affects peripheral joints, making spinal manifestations less common and often overlooked.

Purpose of the Study:

  • To describe five cases of spinal gout to highlight diagnostic challenges.
  • To illustrate the varied presentations and outcomes of gout affecting the spine.

Main Methods:

  • Retrospective review of medical charts for five patients with spinal gout over three years.
  • Analysis of clinical presentation, imaging studies (MRI), laboratory tests, and treatment outcomes.

Main Results:

  • Presentations included discovertebral tophi, facet joint arthritis/cysts, and discitis.
  • Systemic inflammation and elevated uric acid were noted in some patients; prior gout history was uncommon.
  • Histopathology confirmed monosodium urate crystals in spinal lesions.
  • Favorable outcomes were achieved with colchicine or surgical intervention.

Conclusions:

  • Spinal gout presents diagnostic challenges due to its rarity and varied manifestations.
  • Spinal lesions can be the initial presentation of gout, complicating early diagnosis.