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Updated: May 9, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Consequences of gastrointestinal surgery on drug absorption
Rachel Titus1, Andrew Kastenmeier, Mary F Otterson
1Department of Surgery, Michigan State University, 221 Michigan NE, Ste 200A, Grand Rapids, MI 49503, USA. Rachel.Kuznar@grmep.com
Abstract:
Gastrointestinal (GI) surgery associated with resection or bypass can affect the absorption and kinetics of certain drugs. The goal of this article is 3-fold: (1) highlight the physiologic changes associated with selected GI surgeries (specifically gastric, small intestine, and colon), (2) review the implications for drug and nutrient absorption, and (3) suggest modifications of the pharmacologic agents, dosing regimens, and routes of delivery. Few large trials are available to use as references, but there is a wealth of individual reports and small series. Understanding the predictable challenges of drug administration in these patients will improve care.
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