FGF-2 angiogenesis in bone regeneration within critical-sized bone defects in rat calvaria
Risa Kigami1, Shuichi Sato, Noriko Tsuchiya
1Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry, Tokyo, Japan.
Objective:
This study examined the effect of basic fibroblast growth factor (FGF)-2 with an absorbable collagen sponge on angiogenesis and bone regeneration in rat calvarial critical-sized bone defects using microcomputed tomography.
Methods:
Forty 7-week-old male Fischer rats were used. The symmetrical critical-sized calvarial bone defects (5 mm diameter) were created. An absorbable collagen sponge with or without FGF-2 (0.1% or 0.3%) was implanted into each bone defect.
Results:
Blood vessel and bone volumes were significantly higher in the 0.3% FGF-2 group compared with the control and 0.1% FGF-2 groups on day 28. Significantly more osteoblast- and osteoclast-like cells were seen in the 0.3% FGF-2 group.
Conclusions:
Thus, FGF-2 increased blood vessel and bone formation in rat calvarial critical-sized bone defects.
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